David A Jans Selected Research

retinamide

1/2018	Nucleocytoplasmic Trafficking of Dengue Non-structural Protein 5 as a Target for Antivirals.
12/2017	Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection.
12/2014	A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.

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David A Jans Research Topics

Disease

35	Infections 10/2021 - 09/2006
23	Neoplasms (Cancer) 03/2022 - 02/2002
13	Virus Diseases (Viral Diseases) 01/2022 - 06/2003
8	Dengue (Dengue Fever) 01/2022 - 09/2002
6	Respiratory Syncytial Virus Infections 10/2021 - 09/2006
4	Breast Neoplasms (Breast Cancer) 11/2019 - 03/2012
3	Leukemia 12/2021 - 05/2010
3	HIV Infections (HIV Infection) 02/2016 - 12/2003
3	Carcinogenesis 05/2012 - 07/2002
3	Retinoblastoma (Glioblastoma, Retinal) 06/2010 - 01/2005
2	Neoplasm Metastasis (Metastasis) 03/2022 - 08/2007
2	Melanoma (Melanoma, Malignant) 03/2022 - 06/2003
2	Parasitic Diseases (Parasitic Disease) 01/2022 - 01/2020
2	Human Influenza (Influenza) 01/2020 - 01/2017
2	Disease Progression 01/2020 - 08/2005
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2020 - 01/2020
2	Zika Virus Infection 01/2019 - 12/2017
2	Pneumonia (Pneumonitis) 01/2019 - 03/2015
2	Osteosarcoma (Osteogenic Sarcoma) 02/2015 - 12/2008
2	Rabies (Hydrophobia) 12/2011 - 10/2009
2	Acquired Immunodeficiency Syndrome (AIDS) 09/2006 - 03/2003
2	Humoral Hypercalcemia Of Malignancy 01/2003 - 02/2002
1	Triple Negative Breast Neoplasms 03/2022
1	Circulating Neoplastic Cells 03/2022
1	Brain Neoplasms (Brain Tumor) 03/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	COVID-19 01/2020
1	Paramyxoviridae Infections (Parainfluenza) 01/2019
1	Severe Dengue 01/2019
1	Encephalitis (Encephalitis, Rasmussen) 12/2017
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2017
1	Breast Ductal Carcinoma 01/2016
1	Ductal Carcinoma 08/2015
1	Hypersensitivity (Allergy) 08/2015
1	Bronchiolitis 03/2015
1	Common Cold 01/2015
1	Glioma (Gliomas) 08/2014
1	Rotavirus Infections 08/2014
1	Asthma (Bronchial Asthma) 04/2014

Drug/Important Bio-Agent (IBA)

43	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
20	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2008
11	Karyopherins (Importin)IBA 01/2022 - 04/2011
10	Viral ProteinsIBA 01/2019 - 02/2004
9	Inosine Monophosphate (IMP)IBA 01/2022 - 07/2002
7	Pharmaceutical PreparationsIBA 03/2015 - 06/2003
6	DNA (Deoxyribonucleic Acid)IBA 10/2021 - 07/2005
5	Nuclear Localization Signals (Nuclear Localization Signal)IBA 01/2022 - 09/2002
5	VaccinesIBA 11/2019 - 09/2006
4	ChromatinIBA 03/2022 - 07/2005
4	Ivermectin (Mectizan)FDA Link 01/2020 - 10/2018
4	Peptide Hydrolases (Proteases)FDA Link 12/2016 - 07/2009
4	Parathyroid Hormone-Related ProteinIBA 04/2011 - 02/2002
3	CytokinesIBA 01/2019 - 04/2011
3	retinamideIBA 01/2018 - 12/2014
3	Trans-Activators (Trans-Acting Factor)IBA 02/2016 - 12/2003
3	Amino Acids FDA Link 06/2010 - 08/2005
3	alpha KaryopherinsIBA 07/2007 - 01/2002
2	FenretinideIBA 01/2021 - 12/2014
2	Respiratory Syncytial Virus VaccinesIBA 10/2020 - 03/2015
2	Viral RNAIBA 01/2020 - 12/2014
2	Ataxin-1IBA 01/2020 - 01/2020
2	polyglutamineIBA 01/2020 - 01/2020
2	Small Interfering RNA (siRNA)IBA 01/2017 - 08/2015
2	Tumor Viral Antigens (Large T Antigen)IBA 12/2011 - 01/2006
2	Phosphotransferases (Kinase)IBA 09/2011 - 01/2008
2	Retinoblastoma ProteinIBA 04/2011 - 08/2009
2	PhosphoproteinsIBA 07/2010 - 07/2005
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 06/2010 - 01/2005
2	Neoplasm Antigens (Tumor Antigens)IBA 05/2010 - 08/2009
2	Green Fluorescent ProteinsIBA 08/2009 - 01/2006
2	Complementary DNA (cDNA)IBA 02/2008 - 09/2006
1	Protein Kinase CIBA 03/2022
1	8-dehydroxythienamycin (NS 5)IBA 01/2022
1	NucleolinIBA 12/2021
1	Human immunodeficiency virus 1 p31 integrase proteinIBA 01/2020
1	LactonesIBA 01/2020
1	mitoquinoneIBA 11/2019
1	MorpholinosIBA 11/2019
1	Antisense OligonucleotidesIBA 11/2019
1	OligonucleotidesIBA 11/2019
1	Promyelocytic Leukemia ProteinIBA 01/2019
1	Dyneins (Dynein)IBA 01/2019
1	ProteomeIBA 01/2019
1	selinexorIBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2018
1	JNK Mitogen-Activated Protein KinasesIBA 01/2017
1	Cytochromes c (Cytochrome c)IBA 01/2017
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2017
1	PolyproteinsIBA 12/2016
1	3C Viral ProteasesIBA 12/2016
1	STAT1 Transcription FactorIBA 03/2016
1	GoldIBA 01/2016
1	Nucleotide AptamersIBA 01/2016
1	Histones (Histone)IBA 02/2015
1	N-(4-methoxyphenyl)retinamideIBA 12/2014
1	Viroporin ProteinsIBA 02/2014

Therapy/Procedure

12	Therapeutics 10/2020 - 06/2003
2	Drug Therapy (Chemotherapy) 03/2022 - 03/2007
1	Immunotherapy 03/2022